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Abuse Leaves Its Mark on the Brain
By Constance Holden
ScienceNOW Daily News
23 February 2009
Child abuse doesn't just cause emotional problems; it also causes long-lasting changes the brain. A new study shows that in men who were abused as children, a gene involved in stress control is affected even decades later, following a pattern also seen in stressed baby rats.
Rat studies have revealed that maternal neglect alters the workings of the hypothalamic-pituitary-adrenal (HPA) axis, a system that secretes particular hormones in response to stress (ScienceNOW, 2 August 2004). In the abused animals, the regulatory region of a gene for the glucocorticoid receptor, responsible for damping down the HPA response, doesn't do its job properly. As a result, the animals experience chronically higher stress levels.